Cell-penetrating peptides. Methods and protocols
نویسندگان
چکیده
منابع مشابه
Cell Penetrating Peptides
During the last ten years it has been observed that a number of peptides and proteins are able to penetrate the cell membrane and enter the cell. Furthermore, it has been shown that even many cargo molecules that are covalently attached to these peptides will be translocated into the cell. Peptides that show the ability to translocate through the cell membrane are usually short peptides of less...
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Insulin is essential for type 1 and advanced type 2 diabetes to maintain blood glucose levels and increase the patient’s longevity. Frequent subcutaneous insulin injections are usually associated with pain, local tissue necrosis, infection and nerve damage. Recently, a number of new delivery methods such as oral insulin delivery have been developed to overcome these limitations and increase pa...
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Cell-penetrating peptides can translocate across the plasma membrane of living cells and thus are potentially useful agents in drug delivery applications. Disulfide-rich cyclic peptides also have promise in drug design because of their exceptional stability, but to date only one cyclic peptide has been reported to penetrate cells, the Momordica cochinchinensis trypsin inhibitor II (MCoTI-II). M...
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Arginine-rich cell-penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still under investigation. Recent dialogue has centered on a debate over the roles that direct transloc...
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Cell-penetrating peptides (CPPs) mediate the uptake of interconnected cargoes of different types into cells and organisms. Studies in living cells revealed that high-molecular-weight cargoes linked to CPPs are delivered via endocytic routes whereas CPPs by themselves or fused to low-molecular-weight cargoes can in addition enter by a mechanism that does not require vesicle formation. This latte...
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ژورنال
عنوان ژورنال: Biochemistry (Moscow)
سال: 2011
ISSN: 0006-2979,1608-3040
DOI: 10.1134/s000629791112011x